Why are new antifungals needed?

Here are the questions needed to be answered. These are part of a project`s introduction.

1. Why are new antifungals needed?

2. How many classes of antifungals are there?

3. Advantages and disadvantages of Polyenes?

4. Why is genome mining important?

5. How do Complex Polyketide Synthases assemble chains?

Article 1 - Polyene macrolide biosynthesis in streptomycetes and relatedbacteria: recent advances from genome sequencingand experimental studies.